Lifestyle plays a crucial role in shaping health, and new research confirms it. Scientists have found that how you live influences your well-being more than the genes you inherit. The way you eat, move and manage stress directly affects longevity and disease risk, even more than your family history.
The debate between nature and nurture has raged for decades. Researchers at Oxford Population Health analyzed data from nearly 500,000 participants to determine what drives health outcomes. They examined 164 environmental factors alongside genetic risks for 22 age-related diseases.
The results were eye-opening: Lifestyle and environmental factors accounted for 17% of death risk, while genetics contributed only 2%.
Why Lifestyle Matters More Than DNA?
Your daily habits can make or break your health. The study pinpointed key lifestyle choices - smoking, physical activity, and socioeconomic status - that had the biggest impact on mortality.
Smoking alone was linked to 21 diseases, while factors like income and employment status were tied to 19 diseases. Exercise was not far behind, influencing 17 major health conditions.

Master / Pexels / A person’s weight at age 10 and whether their mother smoked during pregnancy could influence health risks decades later.
This suggests that early life choices don’t just shape immediate health but determine how fast or slow a person ages.
You Can Measure How Fast You Age With the ‘Aging Clock’
Scientists have developed a new tool called the “aging clock,” which monitors aging speed based on blood protein levels. This measure links environmental factors with biological aging, helping researchers predict early mortality risks. The study found that lifestyle choices were strong indicators of premature aging, far outweighing genetic risks.
This breakthrough explains why some people with a genetic predisposition to diseases never develop them while others with no family history end up with chronic illnesses. It all comes down to lifestyle - what you eat, how active you are, and the kind of environment you live in.
The Role of Socioeconomic Status in Health
Money may not buy happiness, but it certainly affects health. The study found that socioeconomic factors - such as household income and job stability - were linked to disease risk. Those in lower-income groups had higher chances of developing age-related conditions, even when their genetic risks were low.
People in stable environments with access to healthy food, medical care, and clean air had better health outcomes. Stress from financial instability or unsafe living situations accelerates aging, making lifestyle changes even more critical for long-term well-being.

Cowley / Pexels / Living conditions play a key role in determining your health, the study finds.
Exercise Is the Ultimate Anti-Aging Tool
If there is one lifestyle factor you should prioritize, it is movement. Exercise was shown to reduce the risk of 17 diseases. It strengthens the heart, boosts metabolism, and slows aging at the cellular level. Even moderate activity—like daily walks or stretching—can add years to your life.
Regular physical activity not only prevents disease but also helps manage stress, another key factor in aging. People who exercise regularly produce lower levels of stress hormones, leading to better sleep, improved mental health, and stronger immunity.
Smoking Is the Worst Offender
No lifestyle choice is as damaging as smoking. The study confirmed what doctors have long warned - smoking is tied to 21 diseases and significantly shortens life expectancy. It affects the lungs, heart, and brain, increasing the risk of cancer, stroke, and chronic illness.
Even exposure to secondhand smoke or a mother’s smoking habits during pregnancy can affect a person’s health decades later. Quitting smoking at any age brings immediate benefits, proving that lifestyle changes can reverse the damage and improve health outcomes.